13 Jan 2017
Digital Proteomics at Peptalk 2017
Natalie presented the latest development to Valens and Alicanto at Peptalk 2017. Alicanto is our multi-omic approach to antibody discovery that integrates B-cell transcript sequencing with mass spectrometry-based analysis of serum antibodies. The sequenced repertoire containing tens or hundreds of thousands of sequences is screened using the mass spectra to identify circulating antibodies. Optimized proteomics protocol achieves high antibody coverage of the variable domain and distinguishes with high accuracy small amino acid changes between sequences in the same clonal lineage. Expect more news on Alicanto coming soon!