The role of human antibodies in disease
Humans mount an antibody response to an array of infectious agents across bacteria, fungi, and viruses. Profiling the serum antibody repertoire together with B cell populations can provide critical information for therapeutic development and vaccine design.
Auto-antibodies contribute to many disorders of the immune system, including myasthenia gravis, system lupus erythematosus, and multiple sclerosis. Monitoring serum antibody clonal lineages and isotypes across time and patients can reveal new insights into the disease
B-cell malignancies such as acute myeloid leukemia, multiple myeloma, and non-hodgkins lymphoma produce high serum antibody titers. Characterizing the clonal lineages of the serum antibodies in these disorders can provide important diagnostic information. In solid tumors, anti-tumor antibodies arise to novel cell surface antigens such as abherrant splice variants, modification forms, and fetal proteins. The antibody response in these patients can reveal novel drug targets or direct therapeutic antibody development.